The daily needs of an adult organism in magnesium are 300-400 mg. This level can be achieved with daily consumption of 2-3 ounces (1 ounce = 28.349 g) of roasted pumpkin seeds or 3-4 cups of oat bran. In persons suffering from migraine, the level of magnesium in the blood is usually lowered. Thus, during a special study, the daily use of magnesium preparations in a dose of 600 mg reduced the frequency of migraine attacks by 42%, and the severity of attacks by 34%. The most common side effect of magnesium preparations is diarrhea, which occurs in every fifth patient.
The recommended daily dose of riboflavin in a healthy adult is 1-2 mg. This amount of substance is contained in two cups of milk or yogurt. Riboflavin in high doses (400 mg daily for 3 months) halves the number of migraine attacks without affecting their severity. One study showed that daily consumption of 400 mg of riboflavin drugs has the same prophylactic effect on migraine development as traditional prophylactic drugs.
Coenzyme Q-10, also called “ubiquinone compositum” or CoQ-10, is produced in the body and can come from the outside with meat and seafood. The use of drugs coenzyme Q-10 at a dose of 100 mg three times a day or 150 mg daily for 3 months reduces the frequency of migraine attacks by 27-55%. Daily use of 150 mg of the drug showed greater efficacy, and side effects with the use of both regimens were minimal.
However, coenzyme Q-10 is able to influence glucose metabolism and increase blood clotting, which limits its use in patients with diabetes, impaired coagulation system or taking anticoagulants.