An increase in brain BPD observed in parkinsonism indicates a likely decrease in cerebral pH. The increase in SCP is most pronounced in the frontal areas, which reflects the predominance of disturbances in energy metabolism in the frontal cortex. These changes, at least in part, are associated with impaired neurodynamics as a result of damage to the formations of the nigosstriar system. As a result of treatment with drugs of the l-dopa group, the normal zonal ratios of AMR are restored, and glucose metabolism also normalizes. Another factor possibly contributing to the identified disorders is atrophic processes in the frontal cortex. Acidosis, as evidenced by the increase in SCP, increases the intensity of free-radical processes in the brain and enhances neurodegeneration.
Registration of AMR in patients with Parkinson’s disease may be useful for assessing the severity of disorders of energy processes in patients and monitoring the results of treatment. On the example of the use of l-dopa and parlodel drugs, it is clear that a characteristic sign of parkinsonism — a change in the sign of bipolar difference of SPD between lower frontal and central lead — during treatment has ceased to differ from the norm, which indicates a partial normalization of energy metabolism in the frontal areas.