Parameters of AMR in Parkinsonian patients

The ordinate axis – UPP, mV; the colored bars represent the mean values ​​of the characteristics of the SCP, the uncolored rectangles are the standard error. BP – Parkinson’s disease. The abscissa axis is the parameters of the SCP, the symbols of which are presented in section 4.5.

This pattern of SCP distribution in patients with parkinsonism is explained by the peculiarities of changes in energy metabolism in various areas of the cortex. More pronounced deviations of SCP from the norm in the frontal region are the result of significant disorders of energy metabolism in this part of the brain. The frontal areas receive major ascending projections from the striopally system. In parkinsonism, degenerative processes in the nigrosternal system are accompanied by secondary changes in energy metabolism, which decrease when taking drugs from the l-dopa group (M. Hirato et al., 1995; L. Defebvre et al., 1995; M. Oishi et al. , 1996). In addition, atrophic processes predominate in parkinsonism in the frontal areas of patients with parkinsonism, which also affects energy metabolism. Acidification of the nervous tissue, as evidenced by an increase in UPP,leads to the intensification of free-radical processes that enhance neurodegeneration (E. Roberts, T. Sick, 1996).

The study of SCP was continued by us after the patients were prescribed drugs of the l-dopa group (l-dopa, nakom, madopar) and parlodel, a dopaminergic receptor agonist. When treated with these drugs in standard dosages, clinical improvement was observed: rigidity, tremor and hypokinesia regressed. At this time, re-registration of the SCP was carried out. It was found that in parallel with the improvement of clinical symptoms, the form of AMR was normalized. Against the background of treatment with l-dopa and parlodel, the frontal-central gradient of SCP in patients with parkinsonism was not significantly different from the norm (Fig. 7.11). There were significant differences between this indicator before and during treatment. However, against the background of drug therapy, the values ​​of averaged SCP remained elevated. The ordinate axis – UPP.The painted bars are the arithmetic mean of the frontal-central gradient of the SCP (F-C). Unpainted bars standard error.
The remaining explanations in the text.

So, in Parkinson’s disease, energy metabolism disorders affect the development of the disease. Patients revealed a defect in the enzyme of the mitochondrial respiratory chain – NADH-ubiquinone oxidase, which violates the processes of aerobic oxidation and increases the
neurons damaging oxidative stress. In the caudate nucleus and striatum, cerebral blood flow and glucose consumption are increased, while in the frontal and premotor cortex are reduced. These changes are associated with hyperactivation of striatum cholinergic neurons resulting from the removal of inhibitory control by dopaminergic neurons.

local_offerevent_note August 2, 2019

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