Due to disorders of energy metabolism in asthma, the level of free-radical oxidation increases, which contributes to neurodegeneration, initiating chain reactions of lipid peroxidation (LPO). The FLOOR damages neuronal membranes and can lead to cell death (PF Good et al., 1996)). The formation of crosslinks in the fragments of amyloid precursor protein as a result of a free-radical reaction is a prerequisite for the formation of protease-resistant deposits amyloid (K. Beyreuther et al., 1993). According to the authors, oxidative stress is the primary event triggering the formation of amyloid.
One of the most important factors causing the growth of free radical oxidation, in particular the intensification of POL, is the acidification of nervous tissue. Acidosis reduces the effectiveness of antioxidant protection and disrupts the respiratory chain of mitochondria, which enhances the production of oxygen free radicals (Chapter 1, “Biochemical basis of cerebral energy metabolism”). Therefore, it is highly likely that there is a relationship between SCP, which reflects the dynamics of pH, and the intensity of POL. To test this hypothesis, we studied the correlation between SCP and pentane content in exhaled air in patients with BA. Pentane is the end product of POL and characterizes its intensity. Of great interest is the direct quantitative assessment of the relationship of energy and free-radical processes in the brain during functional load,simulating light stress.
These indicators were investigated at rest and after sound stimulation with a intensity of 90 dB, which can be evaluated as mild stress.
A study of the content of pentane in exhaled air was carried out by the employees of the Laboratory of Clinical Biochemistry of the NCHP of the RAMS (the head was Prof. RR Lideman) Orlov, A.N. Yerin. The results of the work published earlier (VF Fokin et al., 1989; and others).
In the study, a significant correlation was found between the local SCP in the central region and the amount of pentane in the exhaled air prior to sound stimulation ( r = 0.57, p <0.035). Under the influence of sound stimulation, the amount of SCP and the content of pentane in the exhaled air changed. A pronounced relationship was observed between the increment of averaged SCP and the increment of pentane, as well as between the increment of SCP in the occipital region and the increment of pentane .
The ordinate is the pentane content, and the abscissa is the UPP. Dotted lines indicate the 95% confidence interval to the corresponding regression line.
The data obtained allow us to conclude that if the sound stress causes acidification of the nervous tissue, increasing the SCP, this leads to an increase in the POL process. In about half of the cases, the opposite result is observed: under the influence of sound
Stimulation stimulation decreases in all those leads that are listed in the table. 7.3, and this is accompanied by the fall of the FLOOR. This result confirms the in vitro data on the causal relationship between a decrease in cerebral pH and an increase in the intensity of free-radical processes (H. Nohl, V. Koltover, 1994).