Cerebral acidosis, which, according to UPP, is observed to varying degrees in all the pathologies considered (stuttering, drug addiction, consequences of acute cerebral circulation disorders, asthma, parkinsonism, brain tumors), causes secondary disruptions of mitochondria, inhibits neuronal activity and cases of significant pH shifts lead to cell death by the mechanism of apoptosis.
As a rule, the development of cerebral acidosis is associated with an energy deficit, as a result of which ionic pumps of cell membranes are inactivated and partial depolarization of neurons develops. Under these conditions, the neurotoxic effect of the excitatory mediator glutamate is significantly enhanced. Even its usual concentrations become sufficient for the hyperactivation of NMDA receptors, the accumulation of Ca in the cell and the development of calcium-dependent enzymatic reactions that break down cellular structures.
In cases of massive brain damage and BBB, such as strokes, SCP in the affected area falls, reflecting a sharp decrease in energy metabolism in it. In some types of pathology, the correction of SCP and, consequently, changes in pH can be achieved already with psychotherapeutic effects. Such normalization was detected during hypnosis in patients with stuttering. It is probably the result of a decrease in brain activity and leaching of acidic products by increasing cerebral blood flow. However, with more significant and persistent violations of energy metabolism, such as drug addiction, hypnosis does not allow to correct the brain’s ACV.
A significant reduction in AMR during sedation and anesthesia makes it possible to use this method to monitor changes in energy metabolism under the influence of psychotropic drugs.
The high frequency of acidosis in cerebral pathology, detected with the use of SCP and methods of computer visualization of biochemical processes, raises the question of its targeted correction. Currently, the regulation of pH is carried out with resuscitation in the context of acute pathology. However, in chronic diseases of the central nervous system, approaches to pH correction with drugs that shift the cerebral pH to the alkaline side (pH-alkaline shifter) are under development (T. Nakada, IL Kwee, 1993). This treatment is indicated for many diseases. It should be noted that drugs that improve cerebral circulation indirectly contribute to the reduction of acidosis, because they increase aerobic activity and reduce anaerobic energy metabolism.