In patients with BA of the presenile type, the stage of mild dementia SCP in monopolar leads has a tendency to increase, however, differences from the norm are not significant. At the stages of moderate (2a) and severe (2b) dementia, as well as the final stage of the disease (3), higher than the control group of healthy ones, the values of averaged SCP and SCP in all monopolar leads are recorded (Fig. 7.5). No significant differences in local potentials from the norm were revealed. Comparison of SCP with clinical data shows that more severe impairments of intelligence and emotional sphere have higher SCP values. This is understandable if we bear in mind that the accumulation of acid metabolites in the brain tissue is associated with the development of the atrophic process.
The average parameters of SCP of the brain in patients with BA of the presenile type and in the control group of healthy subjects of the same age.
The ordinate axis is the UPP, the colored bars correspond to the mean values of the UPP, the unstained are the standard error. The control is a group of healthy subjects, age-appropriate BA patients. BA (1b), BA (2a), BA (2b), BA (3) are patients with BA in stages 1b, 2a, 2b, and 3, respectively. * marked values of AMR in patients, significantly ( p <0.05) differing from the norm. F, C, O, Td, Ts, {UPP} – parameters of the UPP (see Section 4.5)
In patients suffering from SDAT and BA of the presenile type, there are certain differences in the distribution of AMR. In patients with SDAT in stage 2b, there is an increase in SCP in the left temporal region, a decrease in local SCP in the central lead and an increase in local SCP in the left temporal lead . A decrease in local potential in the central lead is characteristic of a violation of corticotical-subcortical relationships associated with a lesion of the basal ganglia (section 7.4, “Energy chesky exchange in parkinsonism “). Therefore, it can be assumed that in patients with SDAT, atrophic changes predominate in the temporal areas and in the subcortical structures of the brain, while in the case of early asthma, in the cortex. This corresponds to the data of CTG and features of clinical symptoms. BA is characterized by severe amnesia and impairment of higher cortical functions (dysgraphia, dyspraxia and dysgnosis) with long-term preservation of the basic properties of the personality and the emotional sphere, while emotional distress and amnesia disorders dominate with SDAT with a shift in the situation of the past with less significant disruption of higher cortical functions (SI Gavrilova et al., 1992).
Painted bars – arithmetic mean UPP, uncolored – standard error. N – control group of healthy subjects; 2a, 2b – patients with SDAT in stages 2a and 2b, respectively. * marked values of AMR in patients, significantly ( p <0.05) differing from the norm. Ts, C #, Ts # – UPP parameters
Thus, there are significant differences between SCP in normal and dementia of the Alzheimer’s type. In case of BA of the presenile type, violations of the acidoric disorder of acidophilus occur in various areas of the cerebral cortex, in case of LIFT they are generally less pronounced and, judging by the indicators of SCP, are most noticeable in the left temporal region. In addition, a decrease in the local potential in the central region with SDAT indicates a change in neurodynamics as a result of subcortical disorders. Acidosis contributes to the progression of BA, enhancing the abnormal processing of amyloid precursor protein and oxidative stress damaging neurons.