None of the drugs used to relieve headaches can be effective in every attack. For this reason, for an objective assessment of the effectiveness of treatment, any new drug is evaluated in three bouts of headaches.
Often, patients postpone the use of the drug until the maximum amplification of headaches, which reduces the effectiveness of the drug. When conducting clinical trials often reveal the best efficacy of drugs due to the fact that in these cases the drug is taken in an earlier stage of the attack and a higher level of patient compliance is ensured.