Middle-aged cerebral energy metabolism

In healthy middle-aged subjects in a state of calm wakefulness, the intensity of cerebral blood flow varies in different parts of the brain. When studying LMK using the xenon-133 clearance method, it was shown that cerebral blood flow

72 has a hyperfrontal distribution . In the frontal areas located in front of the central and sylvian grooves, cerebral blood flow is approximately two times higher than in the parietal, temporal and occipital cortex. In the lower frontal region, the blood flow intensity is less than in the frontal.

When you say the words out loud and to yourself in the left temporal region, blood flow rises more than in the right. At the same time, in some studies, it was found that in people who did not receive any tasks, LMC prevails in the right hemisphere. The authors attribute this to the emotional activation as a result of participation in the experiment Mente .

However, when studying cerebral blood flow using single-photon emission computed tomography (SPECT), a number of authors did not confirm the presence of a hyperfrontal distribution of cerebral blood flow (I. Podreka et . It was found that the highest level of blood flow occurs in the occipital regions, LMC is less in the frontal, temporal and parietal cortex.

Many studies have found that blood flow in the cerebral cortex in women is slightly higher than in men . Differences in the level of blood flow and hematocrit approximately correspond to each other . Some authors, by contrast, found that LMC in the prefrontal and temporal regions in men is higher than in women .

The differences between men and women in terms of brain glucose intake were also investigated. The results are mixed. In many studies, such differences were not found , while in a number of other studies, a higher level of glucose consumption in women was revealed . The authors attribute such differences to a high level of estrogen, since women were examined from 5 to 15 days of the menstrual cycle.

R. Gur et al. (1995) when examining adult healthy subjects, they found that in a state of calm wakefulness, the level of glucose consumption in both men and women is higher in the associative areas on the left, and in the limbic sections of the temporal lobe – on the right. In men, in the limbic sections of the temporal lobe, the metabolism is higher, and in the cingulate gyrus, lower than in women.

N. Azari et al. (1995) showed that in women, hemisphere correlations prevail between the level of glucose consumption in various areas, and in men, intrahemispheric correlations prevail.

local_offerevent_note September 4, 2019

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