Brain capillary wall (as in other organs) formed by a single thin layer of endothelial cells and a thin layer of basal (core) of the membrane consisting of the trans e tangles thinnest fibrils. Between endothelial cells to a brain Pillyar no intercellular pores or slits, through which the capillaries extend to other various substances, ie. e. there are intimate contacts between them . The described features of the capillary structure provide the blood-brain barrier (BBB). It is believed that the BBB maintains relatively constant composition and properties of the internal environment, protects from getting into the brain norepinephrine, serotonin, and d renalina and other substances which continuously circulate in blood.
Do not pass the blood brain barrier and substances such as Ser and neniya iodine, nitric acid salts, salicylic acid, all Collot and rows, immune body, antibiotics (penicillin and streptomycin). PEM on schyu diffusion freely penetrate into the brain water, urea and gases. Gaza diffusion, n diruyut the brain very quickly. The velocity of water flow and dependent on the n intensity perfusion respective brain areas. Through IU m brane endothelial cells are readily soluble substances in railway and rah. Facilitated diffusion or mediated transport, performs r special carrier molecules. Such molecules are capable of carrying certain substances (amino acids, ions, glucose). Part in e societies is transported from the blood to the neurons with active tran with port directed against a concentration gradient. In this case, and to enjoy the energy obtained as a result of oxidative phosphorylates of Bani, perpetrated in the mitochondria. Thus gematoentsefalich e sky barrier protects the central nervous system result from chuzh e native not peculiar body substances, while providing post claim Leniye to neuron only necessary for its normal functioning and substances. At the same time, as shown by clinical observations and the data content of the liquor, the BBB have certain capabilities, etc. e Dela. It is known, for instance, that through this barrier into the brain readily fall and l Cogolo, chloroform, strychnine, morphine, tetanus toxin.
It is shown that the permeability of the blood-brain barrier can be regulated by the central nervous system. This indirectly indicates the possibility of self-regulation of the functional state of the neurons of the brain due to the change in the influx of components contained in the blood to them.