When treating weak and moderate headaches, acetylsalicylic acid and NSAIDs are more effective; acetaminophen® and opioids are less effective.
With a combination of 100 mg of caffeine with analgesics, reduction of headaches is observed 1.5 times more often.
Therefore, when treating headaches of low and moderate intensity, first-line drugs are combinations of an analgesic with caffeine. In 2006, the European Federation of Neurological Societies (EFNO) published clinical guidelines for the treatment of migraine.
On the basis of evidence-based medicine allocated effective tools that are listed in the table. Drugs of choice are first-line drugs.